1.  In one's way (meaning: forming a hindrance or obstruction)

She is determined to become President of the United States , no matter who is on her way.

=> She doesn’t care what the obstacles will be.  She will do whatever it takes to become President of the United States .

 

2.  Make do with (meaning: Make do with - Accept something less satisfactory because there's no alternative)

There's no coffee, so we'll have to make do with tea.

=> There is no coffee.  Even though coffee is our favorite, we will have to drink tea instead. 

 

 

 

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